Hemos leído sobre ... Síndrome de activación Macrofágica
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Zhang M, Cron RR, Chu N, Nguyen J, Gordon SM, Eloseily EM, Atkinson TP, Weiser P, Walter MR, Kreiger PA, Canna SW, Behrens EM, Cron RQ.
Role of DOCK8 in cytokine storm syndromes.
J Allergy Clin Immunol. 2024 Oct 17:S0091-6749(24)01061-3. doi: 10.1016/j.jaci.2024.10.004. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/39423879/
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Bindoli S, De Matteis A, Mitrovic S, Fautrel B, Carmona L, De Benedetti F.
Efficacy and safety of therapies for Still's disease and macrophage activation syndrome (MAS): a systematic review informing the EULAR/PReS guidelines for the management of Still's disease.
Ann Rheum Dis. 2024 Sep 24:ard-2024-225854. doi: 10.1136/ard-2024-225854. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/39317415/ -
Chandrakasan S, Allen CE, Bhatla D, Carter J, Chien M, Cooper R, et al.
Emapalumab Use in Patients With Rheumatologic Disease-Associated Hemophagocytic Lymphohistiocytosis in the United States: the REAL-HLH Study.
Arthritis Rheumatol. 2024 Sep 8. doi: 10.1002/art.42985. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/39245963/
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Caorsi R, Bertoni A, Matucci-Cerinic C, Natoli V, Palmeri S, Rosina S, Penco F, Malattia C, Consolaro A, Viola S, Papa R, Corcione A, Volpi S, Ravelli A, Gattorno M.
Long-term efficacy of MAS825, a bispecific anti-IL1β and IL-18 monoclonal antibody, in two patients with sJIA and recurrent episodes of MAS.
Rheumatology (Oxford). 2024 Aug 23:keae440. doi: 10.1093/rheumatology/keae440. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/39178016/ -
Behrens EM, de Benedetti F.
Anti-Interferon-γ Therapy for Cytokine Storm Syndromes.
Adv Exp Med Biol. 2024;1448:573-582. doi: 10.1007/978-3-031-59815-9_38.
https://pubmed.ncbi.nlm.nih.gov/39117840/
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Baldo F, Erkens RGA, Mizuta M, Rogani G, Lucioni F, Bracaglia C, et al; PReS MAS/sJIA Working Party and Paediatric Rheumatology International Trial Organization.
Current treatment in macrophage activation syndrome worldwide: a systematic literature review to inform the METAPHOR project.
Rheumatology (Oxford). 2024 Jul 26:keae391. doi: 10.1093/rheumatology/keae391. Epub ahead of print.
https://pubmed.ncbi.nlm.nih.gov/39058514/
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Lee J, Bae KS, Rhim JW, Lee SY, Jeong DC, Kang JH.
Macrophage Activation Syndrome in Children: Update on Diagnosis and Treatment.
Children (Basel). 2024 Jun 21;11(7):755. doi: 10.3390/children11070755.
https://pubmed.ncbi.nlm.nih.gov/39062205/
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Huang S, Liu Y, Yan W, Zhang T, Wang P, Zhu M, et al.
Single center clinical analysis of macrophage activation syndrome complicating juvenile rheumatic diseases.
Pediatr Rheumatol Online J. 2024 May 23;22(1):58. doi: 10.1186/s12969-024-00991-3.
https://pubmed.ncbi.nlm.nih.gov/38783316/
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Ulu K, Aliyev E, Kılıç Könte E, Tanatar A, Türkmen Ş, Doğantan Ş, et al.
Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis on anti-interleukin-1 or -6 therapy.
Rheumatology (Oxford). 2024 Mar 5:keae124. doi: 10.1093/rheumatology/keae124. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/38441301/ -
Maeser A, Biernacka-Zielinska M, Smolewska E.
A MASsive attack: a pediatric case of macrophage activation syndrome complicated by DIC as an onset of systemic juvenile idiopathic arthritis successfully treated with anakinra and review of the literature.
Rheumatol Int. 2024 Mar 19. doi: 10.1007/s00296-024-05570-z. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/38502236/ -
Zhang L, Zhang H, Liu S, Zhang N, Wang Y.
A less common case of anti-MDA5 and anti-Ro52 antibody-positive juvenile dermatomyositis complicated with macrophage activation syndrome.
Clin Case Rep. 2024 Mar 20;12(3):e8613. doi: 10.1002/ccr3.8613.
https://pubmed.ncbi.nlm.nih.gov/38515992/ -
Zhu D, Chen L, Meng J, Wang M, Ma Y, Chen X, et al.
Neutrophil activation biomarker pentraxin 3 for diagnosis and monitoring of macrophage activation syndrome occurrence in adult-onset Still's disease
J Autoimmun. 2024 Mar 8;144:103182. doi: 10.1016/j.jaut.2024.103182. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/38460457/
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Slaney ED, Modica R, Woolnough L, Kafisheh D, Bell-Brunson DH, Elder M.
Case Report: Refractory macrophage activation syndrome requiring high-dose anakinra, emapalumab, and etoposide therapy in early-onset systemic juvenile idiopathic arthritis associated with denoviremia.
Front Pediatr. 2024 Jan 22;11:1336554. doi: 10.3389/fped.2023.1336554.
https://pubmed.ncbi.nlm.nih.gov/38322244/ -
Zhu D, Ying S, Yang C, Li S, Tang S, Sun C, Fang H, Qiao J.
Clinical features of macrophage activation syndrome in adult dermatomyositis: A single-center retrospective case-control study.
Immun Inflamm Dis. 2024 Jan;12(1):e1141. doi: 10.1002/iid3.1141.
https://pubmed.ncbi.nlm.nih.gov/38270325/ -
Yu JY, Kim TH, Kim YJ, Kang HM, Yoo IH, Rhim JW, Lee SY, Jeong DC.
Macrophage activation syndrome in neonatal lupus presenting with fever and rash.
J Rheum Dis. 2024 Jan 1;31(1):49-53. doi: 10.4078/jrd.2023.0039.
https://pubmed.ncbi.nlm.nih.gov/38130956/
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Qian Y, Lu M, Zheng Q.
IL-10 and IFN-γ as markers for early recognition of pediatric systemic lupus erythematosus complicated with macrophage activation syndrome.
Rheumatology (Oxford). 2023 Dec 18:kead678. doi: 10.1093/rheumatology/kead678. Epub ahead of print.
https://pubmed.ncbi.nlm.nih.gov/38109672/
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Batu ED, Sener S, Balık Z, Bayındır Y, Cam V, Kasap Cuceoglu M, Uysal O, Aliyev E, Basaran Ö, Bilginer Y, Özen S.
Is it possible to predict a disease course prone to macrophage activation syndrome at systemic juvenile idiopathic arthritis diagnosis?
Clin Rheumatol. 2023 Nov 28. doi: 10.1007/s10067-023-06828-w.
https://pubmed.ncbi.nlm.nih.gov/38012469/
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Charlesworth JEG, Kavirayani A.
Intravenous anakinra for the treatment of haemophagocytic lymphohistiocytosis/macrophage activation syndrome: A systematic review.
Eur J Haematol. 2023 Sep;111(3):458-476. doi: 10.1111/ejh.14029.
https://pubmed.ncbi.nlm.nih.gov/37344166/ -
Chang Y, Shan X, Ge Y.
Macrophage activation syndrome in juvenile dermatomyositis: a case report and a comprehensive review of the literature.
Pediatr Rheumatol Online J. 2023 Sep 21;21(1):106. doi: 10.1186/s12969-023-00893-w.
https://pubmed.ncbi.nlm.nih.gov/37735702/
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Gullickson M, Nichols L, Scheibe M.
A Novel Therapy for a Rare Condition: Continuous Anakinra Infusion for a Patient With Macrophage Activation Syndrome.
Cureus. 2023 Aug 4;15(8):e42968. doi: 10.7759/cureus.42968.
https://pubmed.ncbi.nlm.nih.gov/37667692/
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Shakoory B, Geerlinks A, Wilejto M, Kernan K, Hines M, Romano M et al.
The 2022 EULAR/ACR points to consider at the early stages of diagnosis and management of suspected haemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS).
Ann Rheum Dis. 2023 Jul 24:ard-2023-224123. doi: 10.1136/ard-2023-224123. Epub ahead of print.
https://pubmed.ncbi.nlm.nih.gov/37487610/ -
Baggio C, Bindoli S, Guidea I, Doria A, Oliviero F, Sfriso P.
IL-18 in Autoinflammatory Diseases: Focus on Adult Onset Still Disease and Macrophages Activation Syndrome.
Int J Mol Sci. 2023 Jul 5;24(13):11125. doi: 10.3390/ijms241311125.
https://pubmed.ncbi.nlm.nih.gov/37446301/
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De Benedetti F, Grom AA, Brogan PA, Bracaglia C, Pardeo M, Marucci G, Eleftheriou D, Papadopoulou C, Schulert GS, Quartier P, Antón J, Laveille C, Frederiksen R, Asnaghi V, Ballabio M, Jacqmin P, de Min C.
Efficacy and safety of emapalumab in macrophage activation syndrome.
Ann Rheum Dis. 2023 Jun;82(6):857-865. doi: 10.1136/ard-2022-223739. Epub 2023 Mar 31.
https://pubmed.ncbi.nlm.nih.gov/37001971/ -
Shimizu M, Nishimura K, Iwata N, Yasumi T, Umebayashi H, Nakagishi Y, et al.
Treatment for macrophage activation syndrome associated with systemic juvenile idiopathic arthritis in Japan.
Int J Rheum Dis. 2023 May;26(5):938-945. doi: 10.1111/1756-185X.14681. Epub 2023 Mar 27.
https://pubmed.ncbi.nlm.nih.gov/36973039/
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De Benedetti F, Grom AA, Brogan PA, Bracaglia C, Pardeo M, Marucci G, Eleftheriou D, Papadopoulou C, Schulert GS, Quartier P, Antón J, Laveille C, Frederiksen R, Asnaghi V, Ballabio M, Jacqmin P, de Min C.
Efficacy and safety of Emapalumab in macrophage activation syndrome.
Ann Rheum Dis. 2023 Mar 31:ard-2022-223739. doi: 10.1136/ard-2022-223739. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/37001971/ -
Kaneko S, Shimizu M, Miyaoka F, Shimbo A, Irabu H, Mizuta M, Nakagishi Y, Iwata N, Fujimura J, Mori M, Morio T.
The dynamics of laboratory markers reflecting cytokine overproduction in macrophage activation syndrome complicated with systemic juvenile idiopathic arthritis.
Clin Immunol. 2023 Mar;248:109270. doi: 10.1016/j.clim.2023.109270.
https://pubmed.ncbi.nlm.nih.gov/36806704/
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Zhang HY, Xiao M, Zhou D, Yan F, Zhang Y.
Platelet and ferritin as early predictive factors for the development of macrophage activation syndrome in children with Kawasaki disease: A retrospective case-control study.
Front Pediatr. 2023 Feb 15;11:1088525. doi: 10.3389/fped.2023.1088525.
https://pubmed.ncbi.nlm.nih.gov/36873655/
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Bindoli S, Galozzi P, Doria A, Sfriso P.
Intravenous anakinra to curb cytokine storm in adult-onset Still's disease and in macrophage activation syndrome: A case series.
Joint Bone Spine. 2023 Jan 6;90(2):105524. doi: 10.1016/j.jbspin.2023.105524. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36623798/ -
Hiyama T, Kurasawa K, Hasegawa A, Miyao T, Tanaka A, Arai S, et al.
Differences and similarities in cytokine profiles of macrophage activation syndrome in systemic lupus erythematosus and adult-onset Still's disease.
Clin Exp Med. 2023 Jan 7. doi: 10.1007/s10238-023-00988-4. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/36611087/
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Levy O, Apel A, Alhdor H, Mizrachi A, Agmon-Levin N, Koren-Michowitz M, Amit-Vazina M.
Ruxolitinib for Refractory Macrophage Activation Syndrome complicating Adult-Onset Still's Disease
Eur J Rheumatol. 2022 Aug 9. doi: 10.5152/eurjrheum.2022.21064. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35943464/ -
Rainone M, Ngo D, Baird JH, Budde LE, Htut M, Aldoss I, Pullarkat VA.
Interferon-γ blockade in CART-cell therapy-associated macrophage activation syndrome/hemophagocytic lymphohistiocytosis.
Blood Adv. 2022 Aug 2:bloodadvances.2022008256. doi: 10.1182/bloodadvances.2022008256. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35917457/
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Kostik MM, Isupova EA, Belozerov K, Likhacheva TS, Suspitsin EN, Raupov R, Masalova VV, Chikova IA, Dubko MF, Kalashnikova OV, Chasnyk VG, Cron RQ.
Standard and increased canakinumab dosing to quiet macrophage activation syndrome in children with systemic juvenile idiopathic arthritis.
Front Pediatr. 2022 Jul 28;10:894846. doi: 10.3389/fped.2022.894846.
https://pubmed.ncbi.nlm.nih.gov/35967555/ -
De Matteis A, Colucci M, Rossi MN, Caiello I, Merli P, Tumino N, Bertaina V, Pardeo M, Bracaglia C, Locatelli F, De Benedetti F, Prencipe G.
Expansion of CD4dimCD8+ T cells characterizes macrophage activation syndrome and other secondary HLH.
Blood. 2022 Jul 21;140(3):262-273. doi: 10.1182/blood.2021013549.
https://pubmed.ncbi.nlm.nih.gov/35500103/
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Wang R, Li T, Ye S, Lv L, Chen S, Wang X, Bao CD, Fu Q.
Short-term, low-dose etoposide in refractory adult-onset Still's disease-associated macrophage activation syndrome.
lin Rheumatol. 2022 May 19. doi: 10.1007/s10067-022-06184-1. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35590113/ -
Ding Y, Ge Y.
Anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis complicated with macrophage activation syndrome.
Ther Adv Chronic Dis. 2022 May 13;13:20406223221098128. doi: 10.1177/20406223221098128.
https://pubmed.ncbi.nlm.nih.gov/35586303/ -
Bossi G, Codazzi AC, Vinci F, Clerici E, Regalbuto C, Crapanzano C, Veraldi D, Moiraghi A, Marseglia GL.
Efficacy of Anakinra on Multiple Coronary Arteries Aneurysms in an Infant with Recurrent Kawasaki Disease, Complicated by Macrophage Activation Syndrome.
Children (Basel). 2022 May 5;9(5):672. doi: 10.3390/children9050672.
https://pubmed.ncbi.nlm.nih.gov/35626849/
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Naniwa T, Yamabe T, Ohmura SI, Uehara K, Tamechika SY, Maeda S, Isogai S, Wada J.
Baseline clinical features predicting macrophage activation syndrome in patients with systemic adult-onset Still's disease receiving interleukin-6 inhibitor treatment.
Int J Rheum Dis. 2022 Jun 19. doi: 10.1111/1756-185X.14371. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35719030/ -
Lahiry P, Naumenko S, Couse M, Liao F, Dominguez D, Knight A, Levy DM, Misztal M, Ng LWK, Hiraki LT.
Hemophagocytic Lymphohistiocytosis Gene Variants in Childhood-Onset SLE with Macrophage Activation Syndrome.
J Rheumatol. 2022 Jun 1:jrheum.211200. doi: 10.3899/jrheum.211200. Epub ahead of print.
https://pubmed.ncbi.nlm.nih.gov/35649546/
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Fingerhutová Š, Jančová E, Doležalová P.
Anakinra in Paediatric Rheumatology and Periodic Fever Clinics: Is the Higher Dose Safe?
Front Pediatr. 2022 Mar 7;10:823847. doi: 10.3389/fped.2022.823847
https://pubmed.ncbi.nlm.nih.gov/35321008/ -
Vagrecha A, Zhang M, Acharya S, Lozinsky S, Singer A, Levine C, Al-Ghafry M, Fein Levy C, Cron RQ.
Hemophagocytic Lymphohistiocytosis Gene Variants in Multisystem Inflammatory Syndrome in Children.
Biology (Basel). 2022 Mar 9;11(3):417. doi: 10.3390/biology11030417.
https://pubmed.ncbi.nlm.nih.gov/35336791/ -
Gartini S, Bougrini Y, Rhazari M, Bourkadi JE.
Macrophagic activation syndrome revealing disseminated multifocal tuberculosis: A case report of a rare clinical situation.
Ann Med Surg (Lond). 2022 Mar 9;76:103487. doi: 10.1016/j.amsu.2022.103487.
https://pubmed.ncbi.nlm.nih.gov/35299938/
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Mathieu AL, Omarjee O, Walzer T, Belot A.
Macrophage involvement in juvenile arthritis onset: LACC1 bridges the gap?.
Med Sci (Paris). 2022 Feb;38(2):133-135. doi: 10.1051/medsci/2021253. Epub 2022 Feb 18.
https://pubmed.ncbi.nlm.nih.gov/35179464/
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AlNouwaiser DN, AlMutairi SS, AlRowailey AS.
Management of Hepatitis A-induced Macrophage Activation Syndrome With Anakinra in Systemic Juvenile Idiopathic Arthritis: A Case Report.
Cureus. 2022 Jan 19;14(1):e21430. doi: 10.7759/cureus.21430.
https://pubmed.ncbi.nlm.nih.gov/35103223/ -
Bindoli S, Giollo A, Galozzi P, Doria A, Sfriso P.
Hyperinflammation after anti-SARS-CoV-2 mRNA/DNA vaccines successfully treated with anakinra: Case series and literature review.
Exp Biol Med (Maywood). 2022 Jan 22:15353702211070290. doi: 10.1177/15353702211070290.
https://pubmed.ncbi.nlm.nih.gov/35068221/
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Shimizu M.
Macrophage activation syndrome in systemic juvenile idiopathic arthritis.
Immunol Med. 2021 Dec;44(4):237-245. doi: 10.1080/25785826.2021.1912893. Epub 2021 May 13.
https://pubmed.ncbi.nlm.nih.gov/33982649/
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Erkens R, Esteban Y, Towe C, Schulert G, Vastert S.
Pathogenesis and Treatment of Refractory Disease Courses in Systemic Juvenile Idiopathic Arthritis: Refractory Arthritis, Recurrent Macrophage Activation Syndrome and Chronic Lung Disease.
Rheum Dis Clin North Am. 2021 Nov;47(4):585-606. doi: 10.1016/j.rdc.2021.06.003.
https://pubmed.ncbi.nlm.nih.gov/34635293/ -
Iyengar VV, Chougule A, Gowri V, Taur P, Prabhu S, Bodhanwala M, Desai MM.
DADA2 presenting as nonimmune hemolytic anemia with recurrent macrophage activation syndrome.
Pediatr Blood Cancer. 2021 Nov 22:e29461. doi: 10.1002/pbc.29461. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34811889/
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Yao H, Wang Y, Wang Z, Zhao J, Deng X, Zhang Z, et al.
The performance of the diagnostic scoring system or criteria for macrophage activation syndrome in systemic juvenile idiopathic arthritis for adult-onset Still's disease. A multicentre case-control study in China.
Clin Exp Rheumatol. 2021 Sep-Oct;39 Suppl 132(5):129-134. Epub 2021 Sep 30.
https://pubmed.ncbi.nlm.nih.gov/34596030/ -
Gouda W, Alsaqabi F, Moshrif A, Abbas AS, Abdel-Aziz TM, Islam MA.
Macrophage activation syndrome triggered by systemic lupus erythematosus flare: successful treatment with a combination of dexamethasone sodium phosphate, intravenous immunoglobulin, and cyclosporine: a case report.
J Med Case Rep. 2021 Oct 7;15(1):497. doi: 10.1186/s13256-021-03072-1.
https://pubmed.ncbi.nlm.nih.gov/34620236/
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Zhang G, Liu W, Zhang X, Liu L.
Rescued from desperation: adult-onset Still's disease with life-threatening interstitial lung disease and macrophage activation: Successful treatment by Tocilizumab.
Z Rheumatol. 2021 Aug 10. doi: 10.1007/s00393-021-01063-7. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34378080/ -
Reiff DD, Cron RQ.
Performance of Cytokine Storm Syndrome Scoring Systems in Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children.
ACR Open Rheumatol. 2021 Aug 25. doi: 10.1002/acr2.11331. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34431626/
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Gao DK, Salomonis N, Henderlight M, Woods C, Thakkar K, Grom AA, Thornton S, Jordan MB, Wikenheiser-Brokamp KA, Schulert GS.
IFN-gamma is essential for alveolar macrophage driven pulmonary inflammation in macrophage activation syndrome CI Insight. 2021 Jul 27:147593. doi:
10.1172/jci.insight.147593. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34314387/ -
Ashkenazi L, Hashkes PJ.
50 Years Ago in The Journal of Pediatrics: Hepatic Dysfunction in Systemic Juvenile Idiopathic Arthritis with Alleviation of Arthritis: The First Description of Macrophage Activation Syndrome?
J Pediatr. 2021 Jul;234:64. doi: 10.1016/j.jpeds.2021.03.042.
https://pubmed.ncbi.nlm.nih.gov/34172168/
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Omkar Phadke, Kelly Rouster-Stevens, Helen Giannopoulos, Shanmuganathan Chandrakasan, Sampath Prahalad.
Intravenous administration of anakinra in children with macrophage activation syndrome.
Pediatr Rheumatol Online J. 2021 Jun 29;19(1):98. doi: 10.1186/s12969-021-00585-3.
https://pubmed.ncbi.nlm.nih.gov/34187503/
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Akturk H, Tanyildiz M, Erbey F, Tasdemir M, Celikyurt A, Gonen E, Bilge I.
Macrophage Activation Syndrome in a Child with Juvenile Idiopathic Arthritis Secondary to SARS-CoV-2.
J Trop Pediatr. 2021 May 24:fmab049. doi: 10.1093/tropej/fmab049. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34028559/
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McGonagle D, Ramanan AV, Bridgewood C.
Immune cartography of macrophage activation syndrome in the COVID-19 era
Nat Rev Rheumatol. 2021 Mar;17(3):145-157. doi: 10.1038/s41584-020-00571-1.
https://pubmed.ncbi.nlm.nih.gov/33547426/ -
Naveen R, Jain A, Muhammed H, Gupta L, Misra DP, Lawrence A, Agarwal V, Misra R, Aggarwal A.
Macrophage activation syndrome in systemic lupus erythematosus and systemic-onset juvenile idiopathic arthritis: a retrospective study of similarities and dissimilarities.
Rheumatol Int. 2021 Mar;41(3):625-631. doi: 10.1007/s00296-020-04763-6.
https://pubmed.ncbi.nlm.nih.gov/33388903/ -
Yamabe T, Ohmura SI, Uehara K, Naniwa T.
Macrophage activation syndrome in patients with adult-onset Still's disease under tocilizumab treatment. A single-center observational study.
Mod Rheumatol. 2021 Mar 10:1-21. doi: 10.1080/14397595.2021.1899565. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/33719871/ -
Paim LB, Landim MLL, Firmino SL, Monteiro CMBE, Cordeiro LR, de Araujo FG, de Carvalho JF.
Canakinumab for Pulmonary Artery Hypertension and Macrophage Activation Syndrome Associated with Uncontrolled Systemic Juvenile Idiopathic Arthritis.
Indian J Pediatr. 2021 Mar 20. doi: 10.1007/s12098-021-03734-4. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/33742412/
FEBRERO 2021
- Horne A, von Bahr Greenwood T, Chiang SCC, Meeths M, Björklund C, Ekelund M, Erensjö P, Berg S, Hagelberg S, Bryceson YT, Andersson U, Henter JI.
Efficacy of moderately dosed etoposide in macrophage activation syndrome - hemophagocytic lymphohistiocytosis (MAS-HLH).
J Rheumatol. 2021 Feb 15:jrheum.200941. doi: 10.3899/jrheum.200941.
https://pubmed.ncbi.nlm.nih.gov/33589555/ -
Guo L, Xu Y, Qian X, Zou L, Zheng R, Teng L, Zheng Q, Leung Jung LK, Lu M.J
Sudden Hypotension and Increased Serum IFN-gamma and IL-10 Predict Early Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis Patients.
Pediatr. 2021 Feb 10:S0022-3476(21)00117-7. doi: 10.1016/j.jpeds.2021.02.008.
https://pubmed.ncbi.nlm.nih.gov/33581106/ -
Aydın F, Çelikel E, Ekici Tekin Z, Coşkun S, Sezer M, Karagöl C, Kaplan MM, Tekgöz N, Kurt T, Özcan S, Kavurt AV, Özkaya Parlakay A, Çelikel Acar B.
Comparison of baseline laboratory findings of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis and multisystem inflammatory syndrome in children.
Int J Rheum Dis. 2021 Feb 7. doi: 10.1111/1756-185X.14078.
https://pubmed.ncbi.nlm.nih.gov/33550678/ -
Naveen R, Jain A, Muhammed H, Gupta L, Misra DP, Lawrence A, Agarwal V, Misra R, Aggarwal A.
Macrophage activation syndrome in systemic lupus erythematosus and systemic-onset juvenile idiopathic arthritis: a retrospective study of similarities and dissimilarities.
Rheumatol Int. 2021 Mar;41(3):625-631. doi: 10.1007/s00296-020-04763-6. Epub 2021 Jan 2.
https://pubmed.ncbi.nlm.nih.gov/33388903/ -
McGonagle D, Ramanan AV, Bridgewood C.
Immune cartography of macrophage activation syndrome in the COVID-19 era
Nat Rev Rheumatol. 2021 Mar;17(3):145-157. doi: 10.1038/s41584-020-00571-1.
https://pubmed.ncbi.nlm.nih.gov/33547426/
- Sag E, Keskin A, Atalay E, Demir S, Cuceoglu MK, Akca UK, Batu ED, Bilginer Y, Ozen S.
Performances of the "MS-score" and "HScore" in the diagnosis of macrophage activation syndrome in systemic juvenile idiopathic arthritis patients.
Rheumatol Int. 2020 Nov 19. doi: 10.1007/s00296-020-04750-x.
https://pubmed.ncbi.nlm.nih.gov/33215249/
- Krei JM, Møller HJ, Larsen JB.
The role of interleukin-18 in the diagnosis and monitoring of hemophagocytic lymphohistiocytosis/macrophage activation syndrome - a systematic review.
Clin Exp Immunol. 2020 Oct 31. doi: 10.1111/cei.13543. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/33128796/
- Ke Y, Lv C, Xuan W, Wu J, Da Z, Wei H, Zhang M, Tan W.
Clinical analysis of macrophage activation syndrome in adult rheumatic disease: A multicenter retrospective study.
Int J Rheum Dis. 2020 Sep 3. doi: 10.1111/1756-185X.13955. Online ahead of print.
https://pubmed.ncbi.nlm.nih.gov/32885598/ - Ruscitti P, Bruno F, Berardicurti O, Acanfora C, Pavlych V, Palumbo P, Conforti A, Carubbi F, Di Cola I, Di Benedetto P, Cipriani P, Grassi D, Masciocchi C, Iagnocco A, Barile A, Giacomelli R.
Lung involvement in macrophage activation syndrome and severe COVID-19: results from a cross-sectional study to assess clinical, laboratory and artificial intelligence-radiological differences.
Ann Rheum Dis. 2020 Sep;79(9):1152-1155. doi: 10.1136/annrheumdis-2020-218048.
https://pubmed.ncbi.nlm.nih.gov/32719039/
- Otsuka R, Seino KI
Macrophage activation syndrome and COVID-19.
Inflamm Regen. 2020 Aug 6;40:19. doi: 10.1186/s41232-020-00131-w.
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Z Rheumatol. 2020 Aug 17. doi: 10.1007/s00393-020-00836-w.
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COVID-19 and Hyperinflammatory Syndrome in Children: Kawasaki Disease with Macrophage Activation Syndrome in Disguise?
Cureus. 2020 Aug 1;12(8):e9515. doi: 10.7759/cureus.9515.
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Comparison of serum cytokine profiles in macrophage activation syndrome complicating different background rheumatic diseases in children.
Rheumatology (Oxford). 2020 Jul 18:keaa299. doi: 10.1093/rheumatology/keaa299. Epub ahead of print.
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Experience with Cidofovir as an adjunctive therapy in a patient of adenovirus-induced macrophage activation syndrome in systemic arthritis.
Clin Rheumatol. 2020 May 17:1–4.
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The Rheumatologist's Role in Covid-19.
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Comparison of serum biomarkers for the diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis during tocilizumab therapy.
Pediatr Res. 2020 Mar 17. doi: 10.1038/s41390-020-0843-4. [Epub ahead of print]https://www.ncbi.nlm.nih.gov/pubmed/32184444
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Tocilizumab modifies clinical and laboratory features of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis.
Pediatr Rheumatol Online J. 2020 Jan 10;18(1):2. doi: 10.1186/s12969-020-0399-1.
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Macrophage Activation Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in Childhood Inflammatory Disorders: Diagnosis and Management.
Paediatr Drugs. 2020 Feb;22(1):29-44. doi: 10.1007/s40272-019-00367-1.
https://www.ncbi.nlm.nih.gov/pubmed/31732958
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World J Pediatr. 2019 Oct 14. doi: 10.1007/s12519-019-00256-0. [Epub ahead of print]
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SEPTIEMBRE 2019
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Benefit of Anakinra in Treating Pediatric Secondary Hemophagocytic Lymphohistiocytosis.
Arthritis Rheumatol. 2019 Sep 12. doi: 10.1002/art.41103. [Epub ahead of print]https://www.ncbi.nlm.nih.gov/pubmed/31513353 - Prencipe G, Bracaglia C, De Benedetti F.
Interleukin-18 in pediatric rheumatic diseases.
Curr Opin Rheumatol. 2019 Sep;31(5):421-427. doi:10.1097/BOR.0000000000000634.
https://www.ncbi.nlm.nih.gov/pubmed/31192813
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High-dose anakinra as treatment for macrophage activation syndrome caused by refractory Kawasaki disease in an infant.
BMJ Case Rep. 2019 Aug 4;12(8).
https://www.ncbi.nlm.nih.gov/pubmed/31383678 - Lin Q, Zhang M, Tang H, Shen Y, Zhu Y, Xu Q, Li X.
Acute pancreatitis and macrophage activation syndrome in pediatric systemic lupus erythematosus: case-based review.
Rheumatol Int. 2019 Aug 3. doi: 10.1007/s00296-019-04388-4.
https://www.ncbi.nlm.nih.gov/pubmed/31377830 - Takakura M, Shimizu M, Irabu H, Sakumura N, Inoue N, Mizuta M, Nakagishi Y, Yachie A.
Comparison of serum biomarkers for the diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis.
Clin Immunol. 2019 Aug 23:108252.
https://www.ncbi.nlm.nih.gov/pubmed/31449879
- Minoia F, Bovis F, Davì S, Horne A, Fischbach M, Frosch M, Huber A, Jelusic M, Sawhney S, McCurdy DK, Silva CA, Rigante D, Unsal E, Ruperto N, Martini A, Cron RQ, Ravelli A; PRINTO, CARRA, the PRCSG and the Histiocyte Society.
Development and initial validation of the MS score for diagnosis of macrophage activation syndrome in systemic juvenile idiopathic arthritis.
Ann Rheum Dis. 2019 Jul 11. pii: annrheumdis-2019-215211. doi: 10.1136/annrheumdis-2019-215211. [Epub ahead of print]
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IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome.
Rheumatology (Oxford). 2019 Jul 20. pii: kez282. doi: 10.1093/rheumatology/kez282. [Epub ahead of print]https://www.ncbi.nlm.nih.gov/pubmed/31326996 - Mizuta M, Shimizu M, Inoue N, Nakagishi Y, Yachie A.
Clinical significance of serum CXCL9 levels as a biomarker for systemic juvenile idiopathic arthritis associated macrophage activation syndrome.
Cytokine. 2019 Jul;119:182-187.
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The Immunology of Macrophage Activation Syndrome.
Front Immunol. 2019 Feb 1;10:119. doi: 10.3389/fimmu.2019.00119. eCollection 2019.
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Systemic juvenile idiopathic arthritis and macrophage activation syndrome: update on pathogenesis and treatment.
Curr Opin Rheumatol. 2018 Sep;30(5):514-520
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Macrophage activation syndrome: early diagnosis is key.
Open Access Rheumatol. 2018 Aug 31;10:117-128. doi: 10.2147/OARRR.S151013. eCollection 2018.
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Anakinra treatment in macrophage activation syndrome: a single center experience and systemic review of literature.
Clin Rheumatol. 2018 Apr 16. doi: 10.1007/s10067-018-4095-1. [Epub ahead of print]https://www.ncbi.nlm.nih.gov/pubmed/29663156 - Arthur VL, Shuldiner E, Remmers EF, Hinks A, Grom AA, Foell D, Martini A, Gattorno M, Özen S, Prahalad S, Zeft AS, Bohnsack JF, Ilowite NT, Mellins ED, Russo R, Len C, Oliveira S, Yeung RSM, Rosenberg AM, Wedderburn LR, Anton J, Haas JP, Rösen-Wolff A, Minden K, Szymanski AM, Thomson W, Kastner DL, Woo P, Ombrello MJ
IL1RN Variation Influences both Disease Susceptibility and Response to Human Recombinant IL-1RA Therapy in Systemic Juvenile Idiopathic Arthritis.
Arthritis Rheumatol. 2018 Apr 2. doi: 10.1002/art.40498. [Epub ahead of print]
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Int Immunol. 2018 Feb 6. doi: 10.1093/intimm/dxy012.
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Features, Treatment and Outcomes of Macrophage Activation Syndrome in Childhood-onset Systemic Lupus Erythematosus.
Arthritis Rheumatol. 2018 Jan 17. doi: 10.1002/art.40417. [Epub ahead of print]https://www.ncbi.nlm.nih.gov/pubmed/29342508 - Schulert GS, Minoia F, Bohnsack J, Cron RQ, Hashad S, KonÉ-Paut I, Kostik M, Lovell D, Maritsi D, Nigrovic PA, Pal P, Ravelli A, Shimizu M, Stanevicha V, Vastert S, Woerner A, de Benedetti F, Grom AA.
Effect of Biologic Therapy on Clinical and Laboratory Features of Macrophage Activation SyndromeAssociated With Systemic Juvenile Idiopathic Arthritis.
Arthritis Care Res (Hoboken). 2017 May 12. doi: 10.1002/acr.23277. [Epub ahead of print]
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Macrophage activation syndrome in Still's disease: analysis of clinical characteristics and survival in paediatric and adult patients.
Clin Rheumatol. 2017 Dec;36(12):2839-2845.
https://www.ncbi.nlm.nih.gov/pubmed/28914368 - Shimizu M, Mizuta M, Yasumi T, Iwata N, Okura Y, Kinjo N, Umebayashi H, Kubota T, Nakagishi Y, Nishimura K, Yashiro M, Yasumura J, Yamazaki K, Wakiguchi H, Okamoto N, Mori M.
Validation of classification criteria of macrophage activation syndrome in Japanese patients with systemic juvenile idiopathic arthritis.
Arthritis Care Res (Hoboken). 2017 Dec 1. doi: 10.1002/acr.23482. [Epub ahead of print]
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[Haemophagocytic syndrome secondary to endocarditis due to Bartonella henselae].
An Pediatr (Barc). 2017 Dec 7. pii: S1695-4033(17)30450-2. doi: 10.1016/j.anpedi.2017.11.004. [Epub ahead of print]
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Advances in immunopathogenesis of macrophage activation syndrome during rheumatic inflammatory diseases: toward new therapeutic targets?
Expert Rev Clin Immunol. 2017 Nov;13(11):1041-1047
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Primary Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome: The Importance of Timely Clinical Differentiation.
J Pediatr. 2017 Oct;189:19-21.e1. doi: 10.1016/j.jpeds.2017.07.025.
https://www.ncbi.nlm.nih.gov/pubmed/28838727 - Minoia F, Bovis F, Davì S, Insalaco A, Lehmberg K, Shenoi S, et al.
Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primary Hemophagocytic Lymphohistiocytosis from Macrophage Activation Syndrome.
J Pediatr. 2017 Oct;189:72-78.e3. doi: 10.1016/j.jpeds.2017.06.005.
https://www.ncbi.nlm.nih.gov/pubmed/28807357
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Primary Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome: The Importance of Timely Clinical Differentiation.
J Pediatr. 2017 Aug 21. pii: S0022-3476(17)30959-9. doi: 10.1016/j.jpeds.2017.07.025. [Epub ahead of print]https://www.ncbi.nlm.nih.gov/pubmed/28838727 - Shimizu M, Inoue N, Mizuta M, Nakagishi Y, Yachie A.
Characteristic elevation of soluble TNF receptor II : I ratio in macrophage activation syndrome with systemic juvenile idiopathic arthritis.
Clin Exp Immunol. 2017 Aug 16. doi: 10.1111/cei.13026. [Epub ahead of print]https://www.ncbi.nlm.nih.gov/pubmed/28815559 - Minoia F, Bovis F, Davì S, Insalaco A, Lehmberg K, Shenoi S, Weitzman S, Espada G, Gao YJ, Anton J, Kitoh T, Kasapcopur O, Sanner H, Merino R, Astigarraga I15, Alessio M, Jeng M, Chasnyk V, Nichols KE, Huasong Z, Li C, Micalizzi C, Ruperto N, Martini A, Cron RQ, Ravelli A, Horne A; Pediatric Rheumatology International Trials Organization, the Childhood Arthritis and Rheumatology Research Alliance, the Pediatric Rheumatology Collaborative Study Group, and the Histiocyte Society.
Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primary Hemophagocytic Lymphohistiocytosis from Macrophage Activation Syndrome.
J Pediatr. 2017 Aug 11. pii: S0022-3476(17)30783-7. doi: 10.1016/j.jpeds.2017.06.005. [Epub ahead of print]https://www.ncbi.nlm.nih.gov/pubmed/28807357 - Huang R, Hayashi Y, Yan X, Bu J, Wang J, Zhang Y, Zhou Y, Tang Y, Wu L, Xu Z, Liu X, Wang Q, Zhou J, Xiao Z, Bridges JP, Marsh RA, Zhang, Jordan MB, Li Y, Huang G
HIF1A is a critical downstream mediator for hemophagocytic lymphohistiocytosis.
Haematologica. 2017 Aug 31. pii: haematol.2017.174979. doi: 10.3324/haematol.2017.174979. [Epub ahead of print]https://www.ncbi.nlm.nih.gov/pubmed/28860338
- Behrens EM, Koretzky GA
Review: Cytokine Storm Syndrome: Looking Toward the Precision Medicine Era.
Arthritis Rheumatol. 2017 Jun;69(6):1135-1143.
https://www.ncbi.nlm.nih.gov/pubmed/?term=28217930 - Juczynska K, Wozniacka A, Waszczykowska E, Zebrowska A.
Lupus erythematosus panniculitis resistant to standard treatment, complicated with macrophage activation syndrome.
Postepy Dermatol Alergol. 2017 Jun;34(3):281-283.
https://www.ncbi.nlm.nih.gov/pubmed/28670262
- Behrens EM, Koretzky GA
Review: Cytokine Storm Syndrome: Looking Toward the Precision Medicine Era.
Arthritis Rheumatol. 2017 Jun;69(6):1135-1143. doi: 10.1002/art.40071.
https://www.ncbi.nlm.nih.gov/pubmed/?term=28217930
- Ahn SS, Yoo BW, Jung SM, Lee SW, Park YB, Song JJ.
Application of the 2016 EULAR/ACR/PRINTO Classification Criteria for Macrophage Activation Syndrome in Patients with Adult-onset Still Disease
J Rheumatol. 2017 Apr 15. pii: jrheum.161286. doi: 10.3899/jrheum.161286. [Epub ahead of print]https://www.ncbi.nlm.nih.gov/pubmed/28412707 - Liu AC, Yang Y, Li MT, Jia Y, Chen S, Ye S, Zeng XZ, Wang Z, Zhao JX, Liu XY, Zhu J, Zhao Y, Zeng XF, Li ZG.
Macrophage activation syndrome in systemic lupus erythematosus: a multicenter, case-control study in China
Clin Rheumatol. 2017 Apr 13. doi: 10.1007/s10067-017-3625-6. [Epub ahead of print]https://www.ncbi.nlm.nih.gov/pubmed/28409239
- Behrens EM, Koretzky GA
Review: Cytokine Storm Syndrome: Looking Toward the Precision Medicine Era.
Arthritis Rheumatol. 2017 Jun;69(6):1135-1143. doi: 10.1002/art.40071.
https://www.ncbi.nlm.nih.gov/pubmed/?term=28217930
- Ahn SS, Yoo BW, Jung SM, Lee SW, Park YB, Song JJ.
Application of the 2016 EULAR/ACR/PRINTO Classification Criteria for Macrophage Activation Syndrome in Patients with Adult-onset Still Disease
J Rheumatol. 2017 Apr 15. pii: jrheum.161286. doi: 10.3899/jrheum.161286. [Epub ahead of print]https://www.ncbi.nlm.nih.gov/pubmed/28412707 - Liu AC, Yang Y, Li MT, Jia Y, Chen S, Ye S, Zeng XZ, Wang Z, Zhao JX, Liu XY, Zhu J, Zhao Y, Zeng XF, Li ZG.
Macrophage activation syndrome in systemic lupus erythematosus: a multicenter, case-control study in China
Clin Rheumatol. 2017 Apr 13. doi: 10.1007/s10067-017-3625-6. [Epub ahead of print]https://www.ncbi.nlm.nih.gov/pubmed/28409239
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Plasma exchange successfully treated macrophage activation syndrome in rheumatoid factor-positive polyarticular juvenile idiopathic arthritis with combined pneumonia.
Int J Rheum Dis. 2017 Mar 22. doi: 10.1111/1756-185X.13064.
https://www.ncbi.nlm.nih.gov/pubmed/28328098 - Ahn SS, Yoo BW, Jung SM, Lee SW, Park YB, Song JJ.
In-hospital mortality in febrile lupus patients based on 2016 EULAR/ACR/PRINTO classification criteria for macrophage activation syndrome.
Semin Arthritis Rheum. 2017 Feb 8. pii: S0049-0172(16)30373-0. doi: 10.1016/j.semarthrit.2017.02.002. [Epub ahead of print]
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Macrophage Activation Syndrome in Scleroderma.
J Clin Rheumatol. 2017 Mar;23(2):120-121. doi: 10.1097/RHU.0000000000000512.
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Macrophage Activation Syndrome: different mechanisms leading to a one clinical syndrome.
Pediatr Rheumatol Online J. 2017 Jan 17;15(1):5. doi: 10.1186/s12969-016-0130-4.
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Macrophage activation syndrome triggered by coeliac disease: a unique case report.
Pediatr Rheumatol Online J. 2016 Dec 9;14(1):66.
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Elevated circulating levels of interferon-γ and interferon-γ-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis.
Ann Rheum Dis. 2017 Jan;76(1):166-172.
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Hemophagocytic lymphohistiocytosis in a patient with Sjögren's syndrome: case report and review.
Rheumatol Int. 2016 Nov 16.
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Macrophage activation syndrome in children with systemic juvenile idiopathic arthritis and systemic lupus erythematosus
Rheumatol Int. 2016 Oct;36(10):1421-9
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Hemophagocytic lymphohistiocytosis: Analysis of 18 cases.
Med Clin (Barc). 2016 Oct 7.
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A xenograft model of macrophage activation syndrome amenable to anti-CD33 and anti-IL-6R treatment.
JCI Insight. 2016 Sep 22;1(15):e88181.
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Haemophagocytic lymphohistiocytosis: an elusive syndrome.
Clin Med (Lond). 2016 Oct;16(5):432-436.
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Prognostic factors of macrophage activation syndrome, at the time of diagnosis, in adult patients affected by autoimmune disease: Analysis of 41 cases collected in 2 rheumatologic centers.
Autoimmun Rev. 2016 Sep 21. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/pubmed/27664384 - Crayne CB, Khatami KS, Galliano G.
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Clin Pediatr (Phila). 2016 Oct;55(11):1001-4.
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Macrophage activation syndrome in children with systemic juvenile idiopathic arthritis and systemic lupus erythematosus.
Rheumatol Int. 2016 Oct;36(10):1421-9.
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Elevated circulating levels of interferon-γ and interferon-γ-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis.
Ann Rheum Dis. 2016 Jun 13. pii: annrheumdis-2015-209020. doi: 10.1136/annrheumdis-2015-209020. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/27296321
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Macrophage activation syndrome: A severe and frequent manifestation of acute pancreatitis in 362 childhood-onset compared to 1830 adult-onset systemic lupus erythematosus patients.
Semin Arthritis Rheum. 2016 Jun;45(6):706-10. doi: 10.1016/j.semarthrit.2015.10.015
http://www.ncbi.nlm.nih.gov/pubmed/26833399
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Macrophage activation syndrome in the era of biologic therapy.
Nat Rev Rheumatol. 2016 Mar 24. doi: 10.1038/nrrheum.2015.179. [Epub ahead of print]
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IDO1 Deficiency Does Not Affect Disease in Mouse Models of Systemic Juvenile Idiopathic Arthritis and Secondary Hemophagocytic Lymphohistiocytosis.
PLoS One. 2016 Feb 25;11(2):e0150075. doi: 10.1371/journal.pone.0150075. eCollection 2016.
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Disruption of vascular endothelial homeostasis in systemic juvenile idiopathic arthritis-associated macrophage activation syndrome: The dynamic roles of angiopoietin-1 and -2.
Cytokine. 2016 Feb 20;80:1-6. doi: 10.1016/j.cyto.2016.02.008. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/26908294
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Rate and Clinical Presentation of Macrophage Activation Syndrome in Patients With Systemic Juvenile Idiopathic Arthritis Treated With Canakinumab.
Arthritis Rheumatol. 2016 Jan;68(1):218-28. doi: 10.1002/art.39407.
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Evidence-based diagnosis and treatment of macrophage activation syndrome in systemic juvenile idiopathic arthritis.
Pediatr Rheumatol Online J. 2015 Dec 3;13(1):55. doi: 10.1186/s12969-015-0055-3.
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Macrophage Activation Syndrome
Hematol Oncol Clin North Am. 2015 Oct;29(5):927-41.
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Development and initial validation of classification criteria for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis.
Arthritis Rheumatol. 2015 Aug 28. doi: 10.1002/art.39332. [Epub ahead of print]
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Canakinumab in Systemic Juvenile Idiopathic Arthritis: Impact on the Rate and Clinical Presentation of Macrophage Activation Syndrome.
Arthritis Rheumatol. 2015 Aug 28. doi: 10.1002/art.39407. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/26314396
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Inhibition of Natural Killer Cell Cytotoxicity by Interleukin-6: Implications for the Pathogenesis of Macrophage Activation Syndrome.
Arthritis Rheumatol. 2015 Aug 5. doi: 10.1002/art.39295. EPUB ahead of print]
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